5-Amino-1MQ 50mg

5-Amino-1MQ 50mg

5-Amino-1MQ is a small molecule research compound that acts as a highly selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in the regulation of cellular methylation and NAD⁺ metabolism. NNMT catalyses the methylation of nicotinamide (vitamin B3), diverting it away from the NAD⁺ salvage pathway and thereby limiting NAD⁺ availability within the cell. Elevated NNMT activity has been linked to metabolic dysfunction, obesity, insulin resistance, certain cancers, and age-related decline in mitochondrial function.

By inhibiting NNMT, 5-Amino-1MQ helps to preserve intracellular nicotinamide, allowing for continued recycling into NAD⁺ via the salvage pathway. NAD⁺ is a central cofactor for mitochondrial oxidative phosphorylation and sirtuin activation, and its maintenance is essential for healthy energy metabolism, DNA repair, and cellular longevity. Restoration of NAD⁺ balance through NNMT inhibition has made 5-Amino-1MQ a molecule of significant interest across multiple areas of research.

Research Areas of Interest

1. Metabolic Health and Obesity

   • Studies in animal models have shown that NNMT inhibition with 5-Amino-1MQ reduces fat mass, increases energy expenditure, and improves glucose tolerance.

   • By preserving NAD⁺ availability, 5-Amino-1MQ supports mitochondrial efficiency, allowing for improved utilisation of energy substrates.

   • This has made it a valuable tool in exploring potential therapeutic strategies for obesity, type 2 diabetes, and metabolic syndrome.

2. Insulin Sensitivity and Glucose Regulation

   • NNMT overexpression is associated with impaired insulin signalling.

   • Research on 5-Amino-1MQ suggests improvements in insulin sensitivity and blood glucose control, indicating its importance in studies of pre-diabetes and metabolic dysfunction.

3. Ageing and Longevity Science

   • NAD⁺ levels naturally decline with age, leading to impaired mitochondrial function, reduced sirtuin activity, and increased susceptibility to age-related diseases.

   • By inhibiting NNMT and sparing NAD⁺, 5-Amino-1MQ provides a promising angle for research into cellular resilience, mitochondrial biogenesis, and healthy ageing.

   • This places it in a similar category of interest to NAD⁺ precursors (such as NR and NMN) but with a unique upstream mechanism of action.

4. Cancer and Fibrosis Research

   • NNMT is overexpressed in a range of cancers (including pancreatic, lung, and gastric cancers), where it promotes tumour progression, angiogenesis, and epigenetic reprogramming.

   • NNMT activity has also been implicated in pathological fibrosis in organs such as the liver and kidneys.

   • 5-Amino-1MQ is therefore being investigated as a research tool for studying epigenetic regulation, tumour metabolism, and fibrotic disease progression.

5. Neuroprotection and Cognitive Function

   • NAD⁺ plays a vital role in neuronal survival, synaptic plasticity, and resistance to neurodegeneration.

   • Preclinical investigations have suggested that NNMT inhibition may protect against neuroinflammation and oxidative stress, making 5-Amino-1MQ of interest in studies of Alzheimer’s, Parkinson’s, and other neurodegenerative conditions.

Summary of Research Potential

5-Amino-1MQ represents a novel and highly targeted approach to manipulating cellular NAD⁺ levels. Unlike NAD⁺ precursors, which supply substrates for the salvage pathway, 5-Amino-1MQ works by preventing NNMT from depleting nicotinamide. This dual action — conserving nicotinamide and boosting NAD⁺ — highlights its potential in research related to metabolism, ageing, mitochondrial health, oncology, and neuroprotection.

Because of its broad involvement in fundamental cellular processes, 5-Amino-1MQ has attracted strong interest as a research tool for exploring the molecular mechanisms underpinning energy balance, cellular resilience, and age-related functional decline.

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Technical Information:

• Synonyms: 5-Amino-1MQ, NNMT inhibitor 5-Amino-1MQ

• Molecular formula: C₁₀H₁₁N₂⁺

• IUPAC Condensed Amino Acid Sequence: N/A

• Molecular Weight: Approximately 159.21g/mol

• CAS Number: 42464-96-0

• PubChem CID: Not published

• Further references: Not published

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Stability: Store lyophilised protein at -20°c. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°c for a limited period of time. The lyophilised protein remains stable until expiry date when stored at -20°c. For more information about storage, click here

Source: Biosynthesis

Reconstitution: Soluble in DMSO and ethanol; limited solubility in pure water, improved solubility in Bacteriostatic water

Usage: Product is prepared for LABORATORY RESEARCH ONLY. 5-Amino-1MQ for sale at Pure Peptides UK is limited to scientific research and education only – Only buy 5-Amino-1MQ if you are a licenced researcher.

* Images for illustration purposes only