Fragment 176-191 2mg
Fragment 176-191 is a synthetic peptide fragment derived from the C-terminal end of human growth hormone (hGH). This fragment encompasses amino acids 176 through 191, and is provided as a lyophilised powder for research use only. It is used in laboratory studies exploring fat metabolism, lipolysis vs lipogenesis balance, and metabolic regulation. The molecule is of interest because it isolates one region of hGH thought to influence fat breakdown without the broader effects of full GH systems.
Research Focus and Areas of Interest
1. Fat Breakdown Mechanisms
Fragment 176-191 has been studied in animal labs for its ability to potentiate lipolysis (the breakdown of fat) and inhibit lipogenesis (conversion of nutrients into fat storage), offering a model for fat metabolism research.
2. Metabolic Regulation Pathways
Researchers look at how this fragment may influence pathways related to insulin sensitivity, glucose metabolism, and the regulation of enzymes like glycogen synthase in rodent models. These investigations help delineate its metabolic footprint.
3. Hormonal Cascade & IGF-1 Interaction
Because Fragment 176-191 is part of hGH, studies explore whether it affects IGF-1 levels or other downstream hormonal cascades—though current evidence is mixed. It’s used to compare effects against full-length GH or modified fragments.
4. Safety and Insulin-Related Effects
Some animal data suggest potential anti-insulin or mild hyperglycaemic effects under certain conditions; researchers are using this to understand trade-offs and safety in metabolic modulation.
Conclusion
Fragment 176-191 is a research-grade peptide fragment of hGH that offers focused insight into fat metabolism, hormonal regulation, and metabolic pathway modulation. Supplied strictly for research use only, it is not intended for therapeutic, diagnostic, or veterinary use.
Technical Information:
• Synonyms: HGH Fragment 176-191; Somatotropin (176-191)
• Modified Single-Letter Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
• IUPAC Condensed Amino Acid Sequence: Tyrosine-Leucine-Arginine-Isoleucine-Valine-Glutamine-Cysteine-Arginine-Serine-Valine-Glutamate-Glycine-Serine-Cysteine-Glycine-Phenylalanine
• Molecular Weight: ~1799.1 g/mol
• CAS Number: 66004-57-7
• PubChem CID: 16131230
• Further References: PubChem Entry
Stability, Source, and Handling
• Stability: Stable up to 36 months when stored at -20 °C or colder, protected from moisture and light.
• Source: Synthesised via solid-phase peptide synthesis; purity generally high with verification by Certificate of Analysis.
• Reconstitution: Dissolve in sterile water or PBS under aseptic conditions; aliquot and freeze at -80 °C after reconstitution to avoid degradation.
• Usage: Product is prepared for LABORATORY RESEARCH ONLY.
