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HCG Peptide

Price range: £49.99 through £189.96

Technical Specifications

Specification	Detail
Product Name	HCG Peptide (Human Chorionic Gonadotropin)
Quantity	5000 IU per vial
Purity	≥98% (HPLC verified)
Form	Lyophilized powder
Appearance	White to off-white lyophilized powder
Molecular Weight	~36,700 Da
CAS Number	9002-61-3
Alpha Subunit	92 amino acids
Beta Subunit	145 amino acids
Target Receptor	Luteinizing hormone/choriogonadotropin receptor (LHCGR)
Half-Life	24-36 hours
Key Research Areas	Male reproductive endocrinology, female reproductive endocrinology, fertility research, androgen research, hypogonadism, cryptorchidism, delayed puberty
Storage (Lyophilized)	2-8°C; protect from light and moisture
Storage (Reconstituted)	2-8°C; use within 30-60 days; do not freeze
Shelf Life	24 months from manufacture date (lyophilized)
Shipping	Ambient temperature with protective packaging
Intended Use	Research and laboratory use only
Documentation	Certificate of Analysis provided with each batch

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Description
Additional information

Premium HCG (Human Chorionic Gonadotropin) for Sale | 5000 IU Lyophilized Powder | ≥98% Purity | 48-Hour Delivery Across EU & UK

HCG Peptide: The Essential Gonadotropin for Advanced Endocrine Research

Buy HCG Peptide EU & UK, eupeptidelap.co.uk is proud to present HCG Peptide (Human Chorionic Gonadotropin), a premium research-grade glycoprotein hormone manufactured to the highest analytical standards. As a trusted peptide vendor uk and leading EU peptide supplier, we provide researchers across Europe with HCG for sale that delivers exceptional purity, consistency, and documented quality for advanced studies in reproductive endocrinology, testicular function, and luteinizing hormone receptor signaling. Buy HCG Peptide EU & UK

Human Chorionic Gonadotropin (HCG) is a glycoprotein hormone composed of two non-covalently linked subunits: an alpha subunit (92 amino acids) identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH), and a unique beta subunit (145 amino acids) that confers biological specificity . First discovered in 1927 by Ascheim and Zondek in the urine of pregnant women, HCG is naturally produced by the syncytiotrophoblast cells of the placenta during pregnancy, where it maintains corpus luteum function and progesterone production .

HCG functions primarily as a potent agonist of the luteinizing hormone/choriogonadotropin receptor (LHCGR), a G protein-coupled receptor expressed predominantly in the testes (Leydig cells) and ovaries (theca and granulosa cells) . Upon binding, HCG activates the cAMP/PKA signaling cascade, stimulating steroidogenesis and promoting the production of testosterone in males and progesterone in females . Unlike LH, which is secreted in a pulsatile manner with a short half-life (approximately 20-30 minutes), HCG has a significantly longer half-life (approximately 24-36 hours), making it a valuable tool for sustained receptor activation studies . Buy HCG Peptide EU & UK

For researchers seeking to buy peptide online EU for investigations into male hypogonadism, testicular function, fertility research, or steroidogenesis pathways, eupeptidelap.co.uk offers this premium research compound with comprehensive documentation, including Certificates of Analysis and batch-specific purity data. Whether your laboratory is based in London, Berlin, Paris, or anywhere in the European Union, our guaranteed 48 hour delivery peptide service ensures your research continues without interruption.

The Scientific Foundation of HCG Peptide Research

Discovery and Historical Significance

HCG was first identified in 1927 by German gynecologists Selmar Ascheim and Bernhard Zondek, who discovered its presence in the urine of pregnant women and developed the first pregnancy test based on this finding . For decades, HCG was used clinically as a diagnostic marker for pregnancy, and later as a therapeutic agent for treating infertility and hypogonadism. Its ability to mimic LH activity and stimulate testosterone production in males has made it a cornerstone of reproductive endocrinology research.

Molecular Structure and Composition

HCG is a heterodimeric glycoprotein with a molecular weight of approximately 36,700 Da . Its structure comprises:

Alpha Subunit (α-hCG): A 92-amino acid polypeptide (14,500 Da) identical to the alpha subunits of LH, FSH, and TSH
Beta Subunit (β-hCG): A 145-amino acid polypeptide (22,500 Da) unique to HCG, conferring biological specificity and longer half-life
Carbohydrate Content: Approximately 30% of the molecular weight is carbohydrate, including sialic acid residues that extend plasma half-life

The unique carboxy-terminal peptide (CTP) of the beta subunit contains four O-linked oligosaccharides that protect HCG from rapid hepatic clearance, contributing to its extended half-life compared to LH .

Mechanism of Action: Luteinizing Hormone Receptor Activation

HCG exerts its effects through specific binding to the luteinizing hormone/choriogonadotropin receptor (LHCGR), a G protein-coupled receptor (GPCR) expressed on Leydig cells in the testes and theca/granulosa cells in the ovaries .

Receptor Binding: HCG binds to LHCGR with high affinity (Kd ≈ 0.2-0.5 nM), triggering conformational changes that activate the receptor’s intracellular signaling domains .

Signal Transduction: Activated LHCGR couples to Gs proteins, stimulating adenylyl cyclase and increasing intracellular cAMP levels . Elevated cAMP activates protein kinase A (PKA), which phosphorylates numerous downstream targets involved in steroidogenesis .

Steroidogenesis: PKA activation leads to increased expression of steroidogenic acute regulatory (StAR) protein, which facilitates cholesterol transport into the mitochondria—the rate-limiting step in steroid hormone synthesis . This cascade results in increased testosterone production in Leydig cells and progesterone production in ovarian cells .

Extended Duration: Due to its glycosylation and sialic acid content, HCG has a plasma half-life of approximately 24-36 hours, significantly longer than LH (20-30 minutes), enabling sustained receptor activation .

Key Research Applications

Male Reproductive Endocrinology Research

HCG is extensively used in studies investigating testicular function, Leydig cell biology, and male fertility:

Leydig Cell Stimulation: Investigate the regulation of testosterone biosynthesis and steroidogenesis
Testicular Development: Study the effects of LH receptor activation on testicular growth and maturation
Spermatogenesis Research: Explore the role of intratesticular testosterone in sperm production
Hypogonadism Models: Investigate therapeutic strategies for primary and secondary hypogonadism

Female Reproductive Endocrinology Research

In female reproductive research, HCG serves as a valuable tool for studying ovarian function:

Ovulation Induction: Study the mechanisms of follicle rupture and oocyte maturation
Corpus Luteum Support: Investigate the role of LH receptor activation in progesterone production
Ovarian Steroidogenesis: Explore the regulation of estradiol and progesterone synthesis
Polycystic Ovary Syndrome (PCOS): Research the pathophysiology of ovarian dysfunction

Fertility and Assisted Reproduction Research

HCG is a critical tool in fertility research and assisted reproductive technologies:

Oocyte Maturation: Study the final stages of oocyte development and meiotic maturation
Embryo Implantation: Investigate the role of HCG in endometrial receptivity and implantation
Luteal Phase Support: Research the maintenance of early pregnancy and progesterone production

Androgen Research

HCG’s ability to stimulate testosterone production makes it valuable for studying androgen physiology:

Testosterone Biosynthesis: Investigate the steroidogenic pathway and rate-limiting steps
Androgen Receptor Research: Study the effects of endogenous testosterone on target tissues
Hypogonadism Models: Explore the mechanisms and treatment of low testosterone states

Cryptorchidism Research

HCG has been studied in models of undescended testes:

Testicular Descent: Investigate the hormonal regulation of gubernacular development
Leydig Cell Function: Study the effects of early HCG exposure on testicular development

Delayed Puberty Research

HCG is used in research models investigating the endocrine regulation of puberty:

Pubertal Onset: Study the role of LH receptor activation in initiating pubertal development
Gonadarche: Investigate the mechanisms of testicular and ovarian maturation

Quality Assurance: Setting the Standard for Research Compounds

Manufacturing Excellence

eupeptidelap.co.uk sources HCG Peptide from certified GMP facilities with rigorous quality control protocols:

HPLC Purity Analysis: ≥98% purity verified by high-performance liquid chromatography
Mass Spectrometry Verification: Molecular weight confirmation via LC-HRMS
Bioactivity Testing: Verified in cell-based assays for LHCGR activation and cAMP production
Batch-Specific Certificates of Analysis: Complete documentation for each production run
Research-Use Only (RUO) Labeling: Full compliance with research compound regulations

Chemical and Product Specifications

Specification	Detail
Product Name	HCG Peptide (Human Chorionic Gonadotropin)
CAS Number	9002-61-3
Molecular Weight	~36,700 Da (heterodimer)
Alpha Subunit	92 amino acids (14,500 Da)
Beta Subunit	145 amino acids (22,500 Da)
Purity	≥98% (HPLC verified)
Potency	5000 IU per vial
Appearance	White to off-white lyophilized powder
Form	Lyophilized powder
Solubility	Soluble in sterile water, bacteriostatic water, or PBS
Target Receptor	Luteinizing hormone/choriogonadotropin receptor (LHCGR)
Half-Life	Approximately 24-36 hours
Storage (Lyophilized)	2-8°C; protect from light and moisture
Storage (Reconstituted)	2-8°C for short-term; do not freeze
Shelf Life	24 months from date of manufacture (lyophilized)
Intended Use	Research and laboratory use only
Documentation	Certificate of Analysis provided with each batch

Stability and Handling Guidelines

Lyophilized Powder Storage: Store lyophilized HCG powder at 2-8°C in a dry, dark environment, protected from light and moisture . Under proper storage conditions, the powder maintains stability for up to 24 months from the date of manufacture. Do not freeze the lyophilized powder .

Reconstitution Protocol:

Allow vial and solvent to reach ambient temperature before opening to prevent condensation
Reconstitute using sterile water or bacteriostatic water according to research protocol
Inject solvent slowly down the inside wall of the vial to minimize foaming
Gently swirl or roll the vial until fully dissolved—do not shake vigorously
Label the vial with the date of reconstitution and concentration (IU/mL)
Refrigerate immediately at 2-8°C

Reconstituted Solution Storage: Reconstituted HCG should be stored at 2-8°C and used within 30-60 days . Do not freeze reconstituted HCG, as freezing may denature the glycoprotein and reduce biological activity. Discard any unused solution after the recommended storage period.

Protection from Light and Moisture:

Store in original packaging protected from light
Keep vials tightly sealed when not in use
Allow refrigerated vials to reach room temperature before opening to prevent condensation.

Key Benefits

Premium Quality Manufacturing: GMP-certified production, ≥98% HPLC-verified purity with lot-specific COAs
Well-Characterized Glycoprotein: Over 90 years of research establishing its biological activity
Potent LHCGR Agonist: High-affinity binding to luteinizing hormone/choriogonadotropin receptors
Extended Half-Life: 24-36 hour duration for sustained receptor activation studies
Testosterone Stimulation: Potent inducer of Leydig cell steroidogenesis in male research models
Ovulation Induction: Critical tool for studying oocyte maturation and follicular rupture
Corpus Luteum Support: Essential for investigating luteal phase function and progesterone production
Fertility Research: Widely used in assisted reproduction and fertility studies
Hypogonadism Models: Valuable for studying primary and secondary hypogonadism
Cryptorchidism Research: Investigated in models of testicular descent and development
Delayed Puberty Studies: Used to study gonadarche and pubertal onset mechanisms
Stable Formulation: 24-month shelf life under proper storage conditions
Comprehensive Documentation: Certificates of Analysis with batch-specific purity data
48-Hour EU & UK Delivery: Rapid shipping to research facilities across Europe
Batch Consistency: Rigorous quality control ensures lot-to-lot reproducibility
EU Sourced: Available from within the European Union

Frequently Asked Questions

Q: What is HCG and how does it work?

A: HCG (Human Chorionic Gonadotropin) is a glycoprotein hormone that acts as a potent agonist of the luteinizing hormone/choriogonadotropin receptor (LHCGR) . It stimulates steroidogenesis in Leydig cells (testosterone production) and theca/granulosa cells (progesterone/estradiol production) through cAMP/PKA signaling .

Q: What is the difference between HCG and LH?

A: HCG and LH share the same receptor (LHCGR) but differ in half-life and structure. HCG has a longer half-life (24-36 hours) due to its glycosylation and sialic acid content, while LH has a short half-life (20-30 minutes) . HCG also contains a unique carboxy-terminal peptide that extends its duration of action .

Q: What purity level can I expect when I buy HCG from eupeptidelap.co.uk?

A: All HCG Peptide from eupeptidelap.co.uk is tested to ≥98% purity by HPLC, with Certificates of Analysis provided with every order . Each batch is individually analyzed, ensuring you receive material suitable for rigorous research applications.

Q: What is the molecular weight and structure of HCG?

A: HCG is a heterodimeric glycoprotein with a molecular weight of approximately 36,700 Da . It consists of an alpha subunit (92 amino acids, 14,500 Da) identical to LH, FSH, and TSH, and a unique beta subunit (145 amino acids, 22,500 Da) that confers biological specificity .

Q: How should I store HCG for long-term stability?

A: Store lyophilized HCG powder at 2-8°C, protected from light and moisture . Under proper storage conditions, the powder maintains stability for up to 24 months. After reconstitution, store at 2-8°C and use within 30-60 days. Do not freeze reconstituted HCG .

Q: What is the solubility of HCG?

A: HCG is soluble in sterile water, bacteriostatic water, or PBS . Reconstitute according to research protocol to achieve desired concentration (typically 500-5000 IU/mL) .

Q: What research areas commonly use HCG?

A: HCG is widely used in male reproductive endocrinology research (Leydig cell stimulation, testicular function, spermatogenesis), female reproductive endocrinology research (ovulation induction, corpus luteum support), fertility and assisted reproduction research, androgen research, hypogonadism models, cryptorchidism research, and delayed puberty studies .

Q: What is the mechanism of action of HCG?

A: HCG binds to the luteinizing hormone/choriogonadotropin receptor (LHCGR), a G protein-coupled receptor . This activates adenylyl cyclase, increases cAMP, activates PKA, and stimulates steroidogenic acute regulatory (StAR) protein expression, leading to increased steroid hormone production .

Q: Do you ship HCG to EU countries?

A: Yes. As a dedicated EU peptide supplier, we ship HCG Peptide to all European Union member states with our guaranteed 48 hour delivery peptide service. Our EU fulfilment centre ensures rapid delivery without customs delays. All shipments use protective packaging to maintain compound integrity during transit.

Q: What documentation do you provide with HCG orders?

A: Every order includes a Certificate of Analysis (COA) with batch-specific purity data . Additional documentation, including HPLC chromatograms and mass spectrometry data, is available upon request for researchers requiring comprehensive analytical verification.

Q: Does HCG cross-react with other hormone receptors?

A: HCG is highly specific for the luteinizing hormone/choriogonadotropin receptor (LHCGR) . Due to its alpha subunit homology, it may have minimal activity at other glycoprotein hormone receptors, but its primary and most potent effects are mediated through LHCGR. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Q: Do you offer bulk quantities of HCG for institutional research?

A: Yes. We accommodate bulk orders for research institutions. Contact our team at sales@eupeptidelap.co.uk for volume pricing, custom requirements, and supply agreements for ongoing research programs. ...........................................

Advance Your Research with HCG Peptide

eupeptidelap.co.uk is your trusted source for HCG Peptide, the premium choice for researchers investigating reproductive endocrinology, testicular function, and LH receptor signaling. With nearly a century of research establishing its role as a potent agonist of the luteinizing hormone/choriogonadotropin receptor, HCG represents a fundamental tool for understanding the molecular mechanisms of steroidogenesis and fertility .

Whether you are exploring Leydig cell biology, designing ovulation studies, investigating hypogonadism mechanisms, or researching fertility pathways, our rigorously tested compound provides the quality and consistency your work demands.

Order today and experience the eupeptidelap.co.uk difference – premium quality, rapid 48-hour delivery across the EU and UK, and expert support for the European research community.

5000 IU	1 Vial, 4 Vial