Premium SLU-PP-332 Research Compound for Sale | 5mg Lyophilized Powder | ≥99% Purity | 48-Hour Delivery Across EU & UK
SLU-PP-332: The Advanced ERR Agonist for Next-Generation Metabolic Research
Buy SLU-PP-332 Peptide EU & UK, eupeptidelap.co.uk is proud to present SLU-PP-332 Peptide, a premium research-grade small molecule compound manufactured to the highest analytical standards. As a trusted peptide vendor uk and leading EU peptide supplier, we provide researchers across Europe with SLU-PP-332 for sale that delivers exceptional purity, consistency, and documented quality for advanced studies in metabolic regulation, exercise physiology, and mitochondrial biogenesis. Buy SLU-PP-332 Peptide EU & UK
SLU-PP-332 is a synthetic small molecule agonist of the estrogen-related receptors (ERRs), a family of nuclear receptors that play a fundamental role in regulating cellular energy metabolism . Discovered through a structure-based drug design approach, SLU-PP-332 has emerged as one of the most promising research compounds for studying metabolic pathways involved in endurance, energy expenditure, and muscle adaptation .
SLU-PP-332 functions by selectively activating all three estrogen-related receptor isoforms: ERRα, ERRβ, and ERRγ . These receptors are master regulators of metabolic gene expression, controlling pathways involved in:
-
Mitochondrial biogenesis and oxidative phosphorylation
-
Fatty acid oxidation and lipid metabolism
-
Glucose homeostasis and insulin sensitivity
-
Exercise adaptation and muscle fiber remodeling
A landmark study published in Science demonstrated that SLU-PP-332 treatment in obese mice significantly increased energy expenditure, enhanced fatty acid oxidation, and prevented weight gain . The compound has been shown to increase exercise capacity in animal models without the need for physical training, establishing it as a powerful tool for investigating exercise mimetic pathways .
For researchers seeking to buy peptide online EU for investigations into metabolic disorders, exercise physiology, or mitochondrial function, eupeptidelap.co.uk offers this premium research compound with comprehensive documentation, including Certificates of Analysis and batch-specific purity data. Whether your laboratory is based in London, Berlin, Paris, or anywhere in the European Union, our guaranteed 48 hour delivery peptide service ensures your research continues without interruption.
The Scientific Foundation of SLU-PP-332 Research
Discovery and Development
SLU-PP-332 was identified through a structure-based drug design campaign targeting the estrogen-related receptors (ERRs), a family of orphan nuclear receptors . Unlike traditional nuclear receptors that require specific ligands for activation, ERRs were initially considered “orphan” receptors with no known endogenous ligands. The development of synthetic agonists like SLU-PP-332 has enabled researchers to probe the functional roles of these receptors in metabolic regulation .
Mechanism of Action: Estrogen-Related Receptor Activation
SLU-PP-332 exerts its effects through selective activation of ERRα, ERRβ, and ERRγ . These receptors are constitutively active and function as master transcriptional regulators of genes involved in cellular energy metabolism.
ERRα (Estrogen-Related Receptor Alpha): The most extensively studied ERR isoform, ERRα is highly expressed in tissues with high energy demands, including heart, skeletal muscle, brown adipose tissue, and kidney . ERRα regulates genes involved in:
-
Mitochondrial biogenesis: PGC-1α, NRF-1, NRF-2, TFAM
-
Oxidative phosphorylation: Components of electron transport chain complexes I-V
-
Fatty acid oxidation: CPT1β, MCAD, LCAD, VLCAD
-
TCA cycle enzymes: SDH, IDH, MDH
-
Antioxidant defense: SOD2, catalase, GPX
ERRβ and ERRγ: These isoforms share significant sequence homology with ERRα and regulate overlapping but distinct sets of metabolic genes . ERRγ is particularly important in pancreatic β-cells and skeletal muscle, where it influences insulin secretion and glucose uptake .
SLU-PP-332 Selectivity Profile
SLU-PP-332 demonstrates high selectivity for ERR family receptors over other nuclear receptors. Key selectivity characteristics include:
| Receptor | Activation by SLU-PP-332 |
|---|---|
| ERRα | Potent agonist (EC₅₀ ~ 20-50 nM) |
| ERRβ | Potent agonist |
| ERRγ | Potent agonist |
| ERα (Estrogen Receptor α) | No significant activation |
| ERβ (Estrogen Receptor β) | No significant activation |
| PPARα | No significant activation |
| PPARγ | No significant activation |
This selectivity profile makes SLU-PP-332 a valuable tool for dissecting ERR-specific effects from other nuclear receptor pathways .
Key Research Applications
Exercise Mimetic and Endurance Research
SLU-PP-332 has garnered significant attention as an exercise mimetic—a compound capable of inducing the beneficial effects of exercise without physical training . This property makes it invaluable for studying the molecular pathways underlying exercise adaptation.
Key findings from preclinical studies include:
-
Increased Running Endurance: SLU-PP-332 treatment in mice resulted in significantly increased running distance and time to exhaustion compared to controls
-
Enhanced Oxidative Metabolism: Treated animals showed increased fatty acid oxidation and improved metabolic flexibility
-
Muscle Fiber Remodeling: The compound induced a shift toward oxidative muscle fibers, characteristic of endurance training
-
Mitochondrial Biogenesis: SLU-PP-332 increased mitochondrial density and function in skeletal muscle
Metabolic Disease Research
SLU-PP-332 has demonstrated significant effects in models of obesity and metabolic syndrome:
-
Weight Reduction: In diet-induced obese mice, SLU-PP-332 treatment significantly reduced body weight gain and fat mass
-
Improved Glucose Homeostasis: The compound improved insulin sensitivity and glucose tolerance
-
Enhanced Energy Expenditure: Treated animals showed increased whole-body energy expenditure and thermogenesis
-
Hepatic Steatosis Reduction: SLU-PP-332 reduced liver fat accumulation in obese models
Mitochondrial Function Studies
As a master regulator of mitochondrial biogenesis and function, SLU-PP-332 is widely used in mitochondrial research:
-
Mitochondrial Biogenesis: Investigate PGC-1α-dependent and independent pathways of mitochondrial formation
-
Oxidative Phosphorylation: Study regulation of electron transport chain components
-
Mitochondrial Dynamics: Examine effects on mitochondrial fusion, fission, and mitophagy
-
Mitochondrial Disease Models: Explore potential therapeutic applications for mitochondrial disorders
Cardiovascular Research
ERRα is highly expressed in cardiac tissue, where it regulates energy metabolism and contractile function. SLU-PP-332 is used to study:
-
Cardiac Metabolism: Investigate substrate utilization (fatty acids vs. glucose) in heart tissue
-
Cardiac Hypertrophy: Explore ERR signaling in pathological cardiac remodeling
-
Ischemia-Reperfusion Injury: Study metabolic adaptations during ischemic stress
Skeletal Muscle Research
SLU-PP-332 is extensively used in muscle biology research:
-
Fiber Type Specification: Investigate molecular mechanisms controlling slow-twitch vs. fast-twitch fiber determination
-
Muscle Wasting: Explore therapeutic approaches for sarcopenia and cachexia
-
Metabolic Flexibility: Study substrate switching between glucose and fatty acids in muscle tissue
Quality Assurance: Setting the Standard for Research Compounds
Manufacturing Excellence
eupeptidelap.co.uk sources SLU-PP-332 from certified GMP facilities with rigorous quality control protocols:
-
HPLC Purity Analysis: ≥99% purity verified by high-performance liquid chromatography
-
Mass Spectrometry Verification: Molecular weight confirmation via LC-HRMS
-
Batch-Specific Certificates of Analysis: Complete documentation for each production run
-
Research-Use Only (RUO) Labeling: Full compliance with research compound regulations
Chemical and Product Specifications
| Specification | Detail |
|---|---|
| Product Name | SLU-PP-332 Peptide (ERR Agonist) |
| CAS Number | 2766700-43-8 |
| Molecular Formula | C₂₅H₂₇ClN₄O₄ |
| Molecular Weight | 482.96 g/mol |
| Purity | ≥99% (HPLC verified) |
| Appearance | White to off-white lyophilized powder |
| Form | Lyophilized powder |
| Solubility | Soluble in DMSO (≥10 mg/mL), limited water solubility |
| Target Receptors | ERRα, ERRβ, ERRγ |
| Storage (Lyophilized) | -20°C; protect from light and moisture |
| Storage (Reconstituted) | 2-8°C for short-term; aliquot and store at -20°C for longer storage |
| Shelf Life | 24 months from date of manufacture (lyophilized) |
| Intended Use | Research and laboratory use only |
| Documentation | Certificate of Analysis provided with each batch |
Stability and Handling Guidelines
Lyophilized Powder Storage: Store lyophilized SLU-PP-332 powder at -20°C in a dry, dark environment, protected from light and moisture . Under proper storage conditions, the powder maintains stability for up to 24 months from the date of manufacture.
Reconstitution Protocol:
-
Allow vial and solvent to reach ambient temperature before opening to prevent condensation
-
Reconstitute using DMSO for stock solutions (≥10 mg/mL). For aqueous solutions, prepare in DMSO first, then dilute with appropriate buffer
-
Inject solvent slowly down the inside wall of the vial to minimize foaming
-
Gently swirl or roll the vial until fully dissolved—do not shake vigorously
-
Label the vial with the date of reconstitution
-
Refrigerate immediately at 2-8°C
Reconstituted Solution Storage: For short-term use, store at 2-8°C. For longer-term storage, aliquot into single-use portions and store at -20°C . Avoid repeated freeze-thaw cycles.
Protection from Light and Moisture:
-
Store in original packaging protected from light
-
Keep vials tightly sealed when not in use
-
Allow refrigerated vials to reach room temperature before opening to prevent condensation
Key Benefits
-
Premium Quality Manufacturing: GMP-certified production, ≥99% HPLC-verified purity with lot-specific COAs
-
Well-Characterized Mechanism: Potent and selective ERRα, ERRβ, and ERRγ agonist
-
Exercise Mimetic Properties: Induces endurance benefits without physical training in animal models
-
Metabolic Research: Enhances energy expenditure, fatty acid oxidation, and mitochondrial biogenesis
-
Obesity Research: Reduces body weight and fat mass in diet-induced obesity models
-
Glucose Homeostasis: Improves insulin sensitivity and glucose tolerance
-
Mitochondrial Function: Potent inducer of mitochondrial biogenesis through PGC-1α pathways
-
Skeletal Muscle Studies: Promotes oxidative fiber type specification and metabolic flexibility
-
Cardiovascular Research: Regulates cardiac metabolism and energy homeostasis
-
Selective ERR Agonist: No significant off-target activity at estrogen receptors or PPARs
-
In Vivo Active: Demonstrated efficacy in preclinical animal models
-
Well-Characterized: Published in high-impact journals including Science
-
Stable Formulation: 24-month shelf life under proper storage conditions
-
Comprehensive Documentation: Certificates of Analysis with batch-specific purity data
-
48-Hour EU & UK Delivery: Rapid shipping to research facilities across Europe
-
Batch Consistency: Rigorous quality control ensures lot-to-lot reproducibility
-
EU Sourced: Available from within the European Union
Frequently Asked Questions
Q: What is SLU-PP-332 and how does it work?
A: SLU-PP-332 is a synthetic small molecule agonist of the estrogen-related receptors (ERRα, ERRβ, and ERRγ) . It activates these nuclear receptors, which are master regulators of genes involved in mitochondrial biogenesis, fatty acid oxidation, and energy metabolism . In animal models, SLU-PP-332 has been shown to increase endurance and prevent weight gain in obese mice .
Q: What purity level can I expect when I buy SLU-PP-332 from eupeptidelap.co.uk?
A: All SLU-PP-332 from eupeptidelap.co.uk is tested to ≥99% purity by HPLC, with Certificates of Analysis provided with every order . Each batch is individually analyzed, ensuring you receive material suitable for rigorous research applications.
Q: What is the molecular weight and CAS number of SLU-PP-332?
A: SLU-PP-332 has a molecular weight of 482.96 g/mol and CAS number 2766700-43-8 . Its molecular formula is C₂₅H₂₇ClN₄O₄ .
Q: How should I store SLU-PP-332 for long-term stability?
A: Store lyophilized SLU-PP-332 powder at -20°C, protected from light and moisture . Under proper storage conditions, the powder maintains stability for up to 24 months. For short-term use, store reconstituted solution at 2-8°C; for longer-term storage, aliquot and store at -20°C .
Q: What is the solubility of SLU-PP-332?
A: SLU-PP-332 is soluble in DMSO at ≥10 mg/mL . It has limited water solubility; for aqueous applications, prepare stock solutions in DMSO and dilute with appropriate buffer .
Q: What research areas commonly use SLU-PP-332?
A: SLU-PP-332 is widely used in exercise mimetic and endurance research, metabolic disease studies, mitochondrial function research, cardiovascular research, and skeletal muscle biology studies .
Q: What is the mechanism of action of SLU-PP-332?
A: SLU-PP-332 is a selective agonist of ERRα, ERRβ, and ERRγ, with no significant activity at estrogen receptors or PPARs . Activation of these receptors induces expression of genes involved in oxidative metabolism, mitochondrial biogenesis, and fatty acid oxidation .
Q: Is SLU-PP-332 legal to purchase for research in the UK and EU?
A: SLU-PP-332 is an investigational compound not approved for human use by the MHRA in the UK or the EMA in the EU . It is sold strictly for research purposes only. The sale of unlicensed compounds under “research use only” labeling is permissible for legitimate research purposes when supplied to qualified buyers such as laboratories and research facilities .
Q: Do you ship SLU-PP-332 to EU countries?
A: Yes. As a dedicated EU peptide supplier, we ship SLU-PP-332 to all European Union member states with our guaranteed 48 hour delivery peptide service. Our EU fulfilment centre ensures rapid delivery without customs delays. All shipments use protective packaging to maintain compound integrity during transit.
Q: What documentation do you provide with SLU-PP-332 orders?
A: Every order includes a Certificate of Analysis (COA) with batch-specific purity data . Additional documentation, including HPLC chromatograms and mass spectrometry data, is available upon request for researchers requiring comprehensive analytical verification.
Q: Has SLU-PP-332 been studied in animal models?
A: Yes. A landmark study published in Science demonstrated that SLU-PP-332 treatment in obese mice significantly increased energy expenditure, enhanced fatty acid oxidation, and prevented weight gain . The compound also increased exercise capacity in animal models without physical training .
Q: Do you offer bulk quantities of SLU-PP-332 for institutional research?
A: Yes. We accommodate bulk orders for research institutions. Contact our team at sales@eupeptidelap.co.uk for volume pricing, custom requirements, and supply agreements for ongoing research programs. ...........................................
Advance Your Research with SLU-PP-332 Peptide
eupeptidelap.co.uk is your trusted source for SLU-PP-332 Peptide, the premium choice for researchers investigating exercise mimetic pathways, metabolic disorders, and mitochondrial function. With over a decade of research since its discovery, SLU-PP-332 has emerged as one of the most potent and selective ERR agonists available for the research community .
Whether you are exploring exercise mimetic mechanisms, designing metabolic studies, investigating mitochondrial biogenesis, or researching cardiovascular metabolism, our rigorously tested compound provides the quality and consistency your work demands. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Order today and experience the eupeptidelap.co.uk difference – premium quality, rapid 48-hour delivery across the EU and UK, and expert support for the European research community.





